鼻内镜手术后使用布地奈德鼻喷雾剂治疗慢性鼻-鼻窦炎伴变应性鼻炎的临床观察 点击下载
| 论文标题： | 鼻内镜手术后使用布地奈德鼻喷雾剂治疗慢性鼻-鼻窦炎伴变应性鼻炎的临床观察 |
| 英文标题： | |
| 中文摘要： | 目的：探讨鼻内镜手术后使用布地奈德鼻喷雾剂治疗慢性鼻-鼻窦炎伴变应性鼻炎的临床疗效及安全性。方法：将120例慢性鼻-鼻窦炎伴变应性鼻炎患者按随机数字表法分为对照组和试验组，各60例。两组患者均行鼻内镜手术。对照组患者术毕1周后给予生理盐水灌洗鼻腔；试验组患者术毕1周后给予布地奈德鼻喷雾剂喷鼻，早晚各1次。两组患者疗程均为3个月。比较两组患者治疗前后变应性鼻炎相关症状评分及临床疗效，利用光镜和电镜对鼻腔黏膜的超微结构进行观察，并统计不良反应发生情况。结果：治疗前，两组患者变应性鼻炎症状评分比较，差异无统计学意义（P＞0.05）；治疗后，两组患者变应性鼻炎症状评分显著降低，且试验组显著低于对照组，差异均有统计学意义（P＜0.05）。试验组患者临床总有效率为94.83％，明显高于对照组的50.00％，差异有统计学意义（P＜0.05）。两组患者治疗后鼻腔黏膜病理性腺体增生及黏膜水肿均明显改善，差异有统计学意义（P＜0.05），但组间比较，差异无统计学意义（P＞0.05）。试验组患者鼻腔黏膜修复时间（3个月）显著短于对照组（6个月），差异有统计学意义（P＜0.05）。两组患者不良反应发生率比较，差异无统计学意义（P＞0.05）。结论：鼻内镜手术后使用布地奈德鼻喷雾剂治疗慢性鼻-鼻窦炎伴变应性鼻炎疗效显著，能明显改善患者变应性鼻炎相关症状，修复鼻腔黏膜的超微结构，且安全性较好。 |
| 英文摘要： | OBJECTIVE： To investigate clinical efficacy and safety of Budesonide nasal spray in the treatment of chronic rhino-sinusitis complicating with allergic rhinitis after endoscopic sinus surgery. METHODS： 120 patients with chronic rhino-sinusitis complicating with allergic rhinitis were divided into control group and trial group by random number table method， with 60 cases in each group. Both groups received endoscopic sinus surgery. Control group received normnl saline for nasal cavity lavage after 1 week of surgery； trial group received Budesonide nasal spray， morning and night， one week after surgery. Both groups received treatment for 3 months. Allergic rhinitis-related symptom score before and 3 months after treatment and clinical efficacies were compared between 2 groups. The ultrastructure of nasal mucosa was observed using light microscope and electron microscope. The incidence of ADR was analyzed statistically. RESULTS： Before treatment， there was no statistical significance in allergic rhinitis symptom score between 2 groups （P＞0.05）； after treatment， allergic rhinitis symptom score of 2 groups were decreased significantly， and the trial group was significantly lower than the control group， with statistical significance （P＜0.05）. Total effective rate of trial group was 94.83％， which was significantly higher than 50.00％ of control group， with statistical significance （P＜0.05）. The nasal mucosa pathologic glands and edema of 2 groups were improved significantly， with statistical significance （P＜0.05）； there was no statistical significance between 2 groups （P＞0.05）. The time of nasal mucosa recovery in trial group （3 months） was significantly shorter than in control group （6 months）， with statistical significance （P＜0.05）. There was no significant difference in the incidence of ADR between 2 groups （P＞0.05）.CONCLUSIONS： Budesonide nasal spray in the treatment of chronic rhino-sinusitis complicating with allergic rhinitis after endoscopic sinus surgery shows significant therapeutic efficacy， and can significantly improve allergic rhinitis-related symptom and recovery ultrastructure of nasal mucosa with good safety. |
| 期刊： | 2017年第28卷第2期 |
| 作者： | 刘学良，雷刚 |
| 英文作者： | LIU Xueliang，LEI Gang |
| 关键字： | 变应性鼻炎；慢性鼻-鼻窦炎；鼻内镜手术；布地奈德鼻喷雾剂 |
| KEYWORDS： | Allergic rhinitis； Chronic rhino-sinusitis； Endoscopic sinus surgery； Budesonide nasal spray |
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