紫杉醇致肌肉酸痛发生情况分析及治疗 点击下载
| 论文标题： | 紫杉醇致肌肉酸痛发生情况分析及治疗 |
| 英文标题： | |
| 中文摘要： | 目的：观察紫杉醇所致肌肉酸痛的发生情况，并观察双氯芬酸钠治疗的疗效和安全性。方法：84例接受紫杉醇化疗的恶性肿瘤患者中共有56例出现紫杉醇所致肌肉酸痛，其中22例女性患者发生中、重度肌肉酸痛，将其随机分为A组（11例）和B组（11例）。A组患者给予双氯芬酸钠缓释片75 mg，口服，每日1次；B组患者给予氨酚曲马多片1片，口服，每日1次，肌肉酸痛难以忍受时给予盐酸布桂嗪注射液100 mg，皮下注射，每日2～3次。两组疗程均为5 d。观察患者肌肉酸痛分布情况及疼痛出现时间和持续时间，A、B组患者疼痛缓解情况及不良反应发生情况。结果：84例患者中，肌肉酸痛发生率为66.67％，其中轻度疼痛占23.81％，中度疼痛占13.10％，重度疼痛占29.76％。56例肌肉酸痛患者中，疼痛最早出现在给药当天，大多数患者出现在用药1～3 d后，主要表现为酸痛，严重疼痛时活动受限，多数伴乏力。A、B组患者疼痛缓解率均为100％，但A组患者不良反应发生率显著低于B组，差异有统计学意义（P＜0.05）。结论：双氯芬酸钠治疗紫杉醇所致肌肉酸痛的疗效与氨酚曲马多相当，且安全性优于氨酚曲马多。 |
| 英文摘要： | OBJECTIVE： To observe the occurrence of paclitaxel（PTX）-induced muscle soreness and therapeutic efficacy and safety of diclofenac sodium. METHODS： Among 84 patients with malignant tumor receiving PTX chemotherapy， 56 patients suffered from PTX-induced muscle soreness， among which 22 female patients suffered from medium and severe muscle soreness and then were randomly divided into group A and B， with 11 cases in each group. Group A was given Diclofenac sodium sustained-release tablet 75 mg orally， once a day； group B was given Paracetamol and tramadol hydrochloride tablets one tablet orally， once a day， and then given Promethazine hydrochloride injection 100 mg subcutaneously， 2-3 times a day when muscle soreness could not be born. Treatment course of both groups lasted for 5 d. The distribution of muscle soreness were observed. The onset time and duration of muscle soreness were also observed as well as pain relief and the occurrence of ADR in group A and B. RESULTS： Among 84 cases， the incidence of muscle soreness was 66.67％， among which mild pain accounted for 23.81％， moderate pain accounted for 13.10％， and severe pain accounted for 29.76％. Among 56 patients with muscle soreness， earliest muscle soreness occurred on the day of medication， and most of muscle soreness occurred on 1-3 days after medication， mainly manifesting as sore， activity limitation when severe， associated with fatigue. The pain relief rate of group A and B were 100％， but the incidence of adverse reactions in group A was significantly lower than group B， with statistical significances （P＜0.05）.CONCLUSIONS： Diclofenac sodium is similar to paracetamol and tramadol hydrochloride in the treatment of PTX-induced muscle soreness，but it is better than paracetamol and tramadol hydrochloride in safety. |
| 期刊： | 2017年第28卷第15期 |
| 作者： | 胡丽丽，董超，王来成，尹弟，朱正秋，高超，黄广清，李晓 |
| 英文作者： | HU Lili，DONG Chao，WANG Laicheng，YIN Di，ZHU Zhengqiu，GAO Chao，HUANG Guangqing，LI Xiao |
| 关键字： | 双氯芬酸钠；氨酚曲马多；紫杉醇；肌肉酸痛；疗效；安全性 |
| KEYWORDS： | Diclofenac sodium； Tramadol； Paclitaxel； Muscle soreness； Efficacy； Safety |
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| 文件大小： | 619.60Kb |
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