地氯雷他定治疗荨麻疹的临床综合评价 点击下载
| 论文标题： | 地氯雷他定治疗荨麻疹的临床综合评价 |
| 英文标题： | |
| 中文摘要： | 目的 多维度评价地氯雷他定治疗荨麻疹的临床综合价值。方法运用文献调查法和专家调研法初步确定基于安全性、有效性、经济性、适宜性、创新性、可及性6个维度的临床综合评价指标；采用德尔菲法和层次分析法对评价指标体系的核心内容进行评价和筛选；采用Likert5级评分法对指标的重要性进行赋值；借助系统评价、药品说明书、专家指南/共识、药品不良反应监测报告等，根据临床综合评价指标体系收集各来源证据并进行定性及定量整合分析；由专家根据地氯雷他定各维度临床综合评价证据进行评分，结合临床综合评价指标体系权重计算得到地氯雷他定三级指标的临床综合评价得分，各指标得分累加即为药品的临床综合评价总分，并与氯雷他定进行比较。结果本研究成功构建地氯雷他定治疗荨麻疹的临床综合评价指标体系，包括6个一级指标、13个二级指标、30个三级指标。地氯雷他定的临床综合评价总分为93.63分，氯雷他定为70.91分。结论地氯雷他定的临床综合价值高于氯雷他定，可为医疗机构临床合理用药、用药目录遴选及国家药物政策完善提供参考依据。 |
| 英文摘要： | OBJECTIVE To eva luate the clinical comprehensive value of desloratadine in the treatment of urticaria. METHODS The clinical comprehensive evaluation index system based on six dimensions such as safety ，effectiveness，economy，suitability， innovation and accessibility were preliminarily determined by using the methods of literature investigation and expert investigation ； the core contents of the evaluation index system were evaluated and screened by Delphi method and analytic hierarchy process ；the importance of the index was assigned by Likert 5-level scoring method ；the evidence from various sources were collected and qualitative and quantitative integration analysis were conducted according to the clinical comprehensive evaluation index system with the help of system evaluation ，drug instructions ，expert guidelines/consensus ，adverse drug reaction monitoring report ，etc； the experts scored its clinical comprehensive value according to the clinical comprehensive evaluation evidence of each dimension of desloratadine ，combined with the weight of the clinical comprehensive evaluation index system ，the clinical comprehensive evaluation score of the tertiary indexes of desloratadine were calculated. The total clinical comprehensive evaluation score was obtained by accumulating the scores of each index ，and compared with loratadine. RESULTS This study successfully constructed the clinical comprehensive evaluation index system of desloratadine in the treatment of urticaria ，including 6 primary indexes ，13 secondary indexes and 30 tertiary indexes. The total clinical comprehensive evaluation score of desloratadine was 93.63 and that of loratadine was 70.91. CONCLUSIONS The clinical comprehensive value of desloratadine is higher than that of loratadine ，which can provide a reference basis for clinical rational drug use in medical institutions ，selection of drug use catalogue and improvement of national drug policy. |
| 期刊： | 2022年第33卷第10期 |
| 作者： | 刘璐，甄路路，任美娟，李蕊，刘畅，闫美兴 |
| 英文作者： | LIU Lu，ZHEN Lulu，REN Meijuan ，LI Rui，LIU Chang ，YAN Meixing |
| 关键字： | 地氯雷他定；氯雷他定；荨麻疹；临床综合评价；德尔菲法；层次分析法 |
| KEYWORDS： | desloratadine；loratadine；urticaria；clinical comprehensive evaluation ；Delphi method ；analytic hierarchy process |
| 总下载数： | 81次 |
| 本日下载数： | 2次 |
| 本月下载数： | 81次 |
| 文件大小： | 619.60Kb |
* 注：未经本站明确许可，任何网站不得非法盗链资源下载连接及抄袭本站原创内容资源!在此感谢您的支持与合作！