多维铁口服溶液与多糖铁复合物胶囊治疗妊娠期缺铁性贫血的成本-效果分析 点击下载
| 论文标题： | 多维铁口服溶液与多糖铁复合物胶囊治疗妊娠期缺铁性贫血的成本-效果分析 |
| 英文标题： | |
| 中文摘要： | 目的：探讨多维铁口服溶液和多糖铁复合物胶囊治疗妊娠期缺铁性贫血的成本和效果。方法：采用回顾性研究方法，将80例妊娠期缺铁性贫血患者按照不同治疗方案分成对照组与试验组，各40例。对照组患者口服多维铁口服溶液，每次10 ml，bid，早晚餐后服用，连续4周；试验组患者口服多糖铁复合物胶囊，每次0.30 g，qd，连续4周。比较两组患者的临床疗效、红细胞相关实验室检查指标、满意率及不良反应，并采用成本-效果分析法进行经济学评价。结果：试验组患者的总有效率为95.0％，对照组为85.0％，组间比较差异无统计学意义（P＞0.05）；试验组患者的血红蛋白水平、红细胞计数、平均红细胞体积，均明显高于或大于对照组，满意率也明显高于对照组（95.0％ vs.65.0％），差异均有统计学意义（P＜0.05）；两组患者均未见明显不良反应发生。试验组和对照组的总成本分别为243.60、166.32元，成本-效果比分别为2.56、1.96，增量成本-效果比为7.73；敏感度分析结果与此结果基本相同。结论：多维铁口服溶液和多糖铁复合物胶囊均能够改善妊娠期缺铁性贫血患者的贫血症状，其中多维铁口服溶液更经济；多糖铁复合物胶囊的疗效更佳、患者满意率更高，但由于该药价格相对较贵，临床上可根据患者经济情况选择药物。 |
| 英文摘要： | OBJECTIVE： To investigate the effect and cost of Multidimensional iron oral liquid and Polysaccharide iron complex capsules in the treatment of iron deficiency anemia during pregnancy. METHODS： By retrospective study， 80 cases of iron deficiency anemia during pregnancy were divided into control group and trial group in accordance to different therapy plans， with 40 cases in each group. Control group was given Multidimensional iron oral liquid orally， 10 ml each time， bid， after breakfast and supper， for consecutive 4 weeks； trial group was given Polysaccharide iron complex capsules orally， 0.30 g each time， qd， for consecutive 4 weeks. Clinical efficacy， erythrocyte related lab indexes， satisfactory rate and ADR were compared between 2 groups， and cost-effectiveness analysis was adopted for economic evaluation. RESULTS： The total effective rate of experimental group was 95.0％， which was higher than 85.0％ of control group， but without statistical significance （P＞0.05）； hemoglobin level， erythrocyte count and average volume of erythrocyte of trial group were significantly higher or more than control group， and satisfactory rate （95.0％ vs. 65.0％） were significantly higher than control group， with statistical significance （P＜0.05）； no obvious ADR was found in 2 groups. Total cost of trial group and control group were 243.60 and 166.32 yuan， and cost-effective ratio was 2.56 and 1.96； incremental cost-effective ratio was 7.73. Results of sensitivity analysis were same to the result. CONCLUSIONS： Both Multidimensional iron oral liquid and Polysaccharide iron complex capsules can improve anemia in patients with iron deficiency anemia during pregnancy. Polysaccharide iron complex capsules show better therapeutic efficacy and satisfactory rate， but it is relatively expensive. Drugs should be selected according to economic situation. |
| 期刊： | 2016年第27卷第20期 |
| 作者： | 江少坤，孟婧婧，林慧文，杨丽娟，王立 |
| 英文作者： | JIANG Shaokun，MENG Jingjing，LIN Huiwen，YANG Lijuan，WANG Li |
| 关键字： | 多维铁口服溶液；多糖铁复合物胶囊；妊娠期缺铁性贫血；成本-效果分析 |
| KEYWORDS： | Multidimensional iron oral liquid； Polysaccharide iron complex capsules； Ischemic anemia during pregnancy； Cost-effectiveness analysis |
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