替吉奥联合3D-CRT与微波热疗治疗老年局部晚期食管癌的临床观察 点击下载
| 论文标题： | 替吉奥联合3D-CRT与微波热疗治疗老年局部晚期食管癌的临床观察 |
| 英文标题： | |
| 中文摘要： | 目的：观察替吉奥联合三维适行放射治疗（3D-CRT）与微波热疗治疗老年局部晚期食管癌的临床疗效及安全性。方法：将48例局部晚期老年食管癌患者按随机数字表法分为A、B、C组，各16例。A组患者给予局部3D-CRT，总剂量60～66 Gy，共治疗6～7周；B组患者在A组基础上口服替吉奥60 mg/（m2·d），bid，3周为1个疗程，直到放疗结束；C组患者在B组基础上行微波热疗，3周为1个疗程，直到放疗结束。比较3组患者放疗结束后，临床疗效、1年生存率及吞咽困难、体质量、卡氏（KPS）评分变化情况，并观察3组患者主要毒副反应（放射性食管炎、放射性肺炎、胃肠道反应、骨髓抑制）发生情况。结果：C组患者总有效率为93.75％，1年生存率为87.50％，吞咽困难缓解率为93.75％。明显高于A组的50.00％、50.00％、56.25％和B组的68.75％、68.75％、68.75％，差异均有统计学意义（P＜0.05）。3组患者体质量增加率及KPS评分增加率比较，差异均无统计学意义（P＞0.05）。C组患者放射性食管炎、肺炎发生率均显著低于A组和B组，差异均有统计学意义（P＜0.05）；3组患者胃肠道反应、骨髓抑制发生率比较，差异均无统计学意义（P＞0. 05）。结论：替吉奥联合3D-CRT与微波热疗能显著提高老年局部晚期食管癌的临床疗效和生存率，且毒副反应相对较低。 |
| 英文摘要： | OBJECTIVE： To observe clinical efficacy and safety of tegafur gimeracil oteracil potassium combined with 3D-CRT and microwave hyperthermia in the treatment of elderly patients with local advance esophageal cancer. METHODS： 48 cases of local advance esophageal cancer were divided into group A， B and C according to random number table method， with 16 cases in each group according to random number table method. Group A was given 3D-CRT with total dose of 60-66 Gy totnlly for 6-7 weeks； group B was additionally given tegafur gimeracil oteracil potassium 60 mg/（m2·d）， bid， on the basis of group A 3 weeks for a course of treatment， until the end of radvotherapy； group C was additionally given thermotherapy on the basis of group B 3 weeks for a course of treatment， until the end of radvotherapy. Clinical efficacy， 1-year survival rate， dysphagia， weight and KPS score were compared among 3 groups， and the occurrence of toxic reactions （radioactive esophagitis， radioactive pneumonia， bone marrow suppression and gastrointestinal reaction） were observed in 3 groups. RESULTS： Total effective rate， 1-year survival rate and the remission rate of dysphagia of group C were 93.75％， 87.50％ and 93.75％， which were significantly higher than those of group A （50.00％， 50.00％ and 56.25％） and B （68.75％， 68.75％ and 68.75％）， with statistical significance （P＜0.05）. There was no statistical significance in the rate of weight gain and KPS score gain among 3 groups （P＞0.05）. The incidence of radioactive esophagitis and radioactive pneumonia in group C were significantly lower than in group A and B， with statistical significance （P＜0.05）； there was no statistical significance in the incidence of gastrointestinal reaction and bone marrow suppression among 3 groups （P＞0.05）. CONCLUSIONS： Tegafur gimeracil oteracil potassium combined with 3D-CRT and microwave hyperthermia in the treatment of elderly patients with local advance esophageal cancer further improves clinical efficacy and survival rate， but shows low incidence of toxic reaction. |
| 期刊： | 2016年第27卷第26期 |
| 作者： | 沙莎，霍明昌，王茂玉，李茂江 |
| 英文作者： | SHA Sha，HUO Mingchang，WANG Maoyu，LI Maojiang |
| 关键字： | 替吉奥；微波热疗；三维适形放疗；局部晚期食管癌；疗效；毒副反应 |
| KEYWORDS： | Tegafur gimeracil oteracil potassium； Microwave hyperthermia； 3D-CRT； Local advance esophageal cancer； Efficacy； Toxic reaction |
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