基于AMPK信号通路探讨中药干预肌少症的研究进展 点击下载
| 论文标题： | 基于AMPK信号通路探讨中药干预肌少症的研究进展 |
| 英文标题： | |
| 中文摘要： | 肌少症是一种以骨骼肌质量减少与功能进行性下降为特征的系统性骨骼肌疾病，其发生发展涉及多条信号通路。其中，AMP活化的蛋白质激酶（AMPK）信号通路作为调控细胞能量稳态的关键通路，能够改善糖脂代谢异常、平衡骨骼肌蛋白的合成与降解、改善线粒体功能、促进细胞自噬、抑制炎症反应与氧化应激，在骨骼肌代谢调节与功能维持中发挥重要作用。本文主要综述多酚类、黄酮类、萜类等多种中药单体，中药枸杞、阿胶、西洋参等的提取物以及归芪壮筋汤、健脾强肌颗粒、芪骨胶囊等中药复方通过调控AMPK信号通路促进肌蛋白合成、抑制蛋白降解、改善线粒体功能及减轻炎症与氧化应激，从而干预肌少症的研究进展，并探讨其分子机制，旨在深入阐释中药防治肌少症的作用基础，为相关创新药物的开发提供理论支撑。 |
| 英文摘要： | arcopenia is a systemic skeletal muscle disorder characterized by a decrease in skeletal muscle mass and progressive decline in function， with multiple signaling pathways involved in its occurrence and development. Among them， the AMP-activated protein kinase （AMPK） signaling pathway， as a key pathway regulating cellular energy homeostasis， plays an important role in the regulation of skeletal muscle metabolism and functional maintenance by improving abnormalities in glucose and lipid metabolism， balancing skeletal muscle protein synthesis and degradation， improving mitochondrial function， promoting autophagy， and inhibiting inflammatory responses and oxidative stress. This article reviews the research progress on how various traditional Chinese medicine （TCM） monomers， including polyphenols， flavonoids， and terpenoids； various traditional Chinese medicine extracts， such as those from Lycium barbarum ， Asini Corii Colla， and Panax quinquefolium ， and TCM compounds， such as Guiqi zhuangjin decoction， Jianpi qiangji granules， and Qigu capsules， intervene in sarcopenia by regulating the AMPK signaling pathway to promote muscle protein synthesis， inhibit protein degradation， improve mitochondrial function， and alleviate inflammation and oxidative stress. Additionally， their molecular mechanisms are explored. The aim is to deeply elucidate the basis of TCM in the prevention and treatment of sarcopenia and to provide theoretical support for the development of related innovative drugs. |
| 期刊： | 2026年第37卷第09期 |
| 作者： | 范文玉；黄柏融；洪聪敏；陈言；王佳音；高静；冯晓东 |
| 英文作者： | FAN Wenyu，HUANG Bairong，HONG Congmin，CHEN Yan，WANG Jiayin，GAO Jing，FENG Xiaodong |
| 关键字： | 肌少症；AMPK；中药单体；中药提取物；中药复方 |
| KEYWORDS： | sarcopenia； AMPK； traditional Chinese medicine monomer； traditional Chinese medicine extract； traditional |
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