杜鹃素药理活性及作用机制研究进展 点击下载
| 论文标题： | 杜鹃素药理活性及作用机制研究进展 |
| 英文标题： | |
| 中文摘要： | 杜鹃素是从杜鹃花科植物兴安杜鹃的干燥叶中提取的一种二氢黄酮类化合物。本文系统梳理了杜鹃素的国内外相关研究，对其药理活性和作用机制进行归纳总结，发现其可通过维持血管内皮功能稳态、抑制血管内膜增生等发挥心脑血管保护作用；可通过激活核转录因子红系2相关因子2（Nrf2）信号通路减轻肾损伤，发挥肾保护作用；可通过抑制磷脂酰肌醇3-激酶/蛋白激酶B信号通路，激活Nrf2信号通路，改善胰岛素抵抗、肝脏脂质沉积，发挥肝保护作用；可通过激活Nrf2/Keap1信号通路，抑制Toll样受体4、环磷酸鸟苷-腺苷合成酶/干扰素基因刺激蛋白信号通路，减轻神经炎症损伤，发挥神经保护作用；可通过促进肌腱生成、抑制破骨细胞分化，发挥骨保护作用；可通过诱导肿瘤细胞凋亡、减弱肿瘤细胞侵袭与转移能力，发挥抗肿瘤作用；可通过下调α-毒素表达、干扰β-内酰胺酶/青霉素结合蛋白2a（PBP2a）表达、抑制PBP2a寡聚化等，发挥抗菌作用。目前，杜鹃素的药理作用研究仍以动物实验和细胞实验为主，后续仍需开展更深入的机制研究及临床试验，为其新药研发与临床应用提供理论依据。 |
| 英文摘要： | Farrerol is a dihydroflavone compound extracted from the dried leaves of Rhododendron dauricum belonging to the Ericaceae family. This article systematically reviews relevant research on farrerol both domestically and internationally， summarizes its pharmacological activities and mechanisms of action， and finds that it exerts cardiovascular and cerebrovascular protective effects by maintaining the homeostasis of vascular endothelial function and inhibiting vascular intimal hyperplasia； exerts renal protective effects by activating the nuclear factor erythroid 2-related factor 2 （Nrf2） signaling pathway to reduce renal damage； exerts liver protective effects by inhibiting the phosphatidylinositol 3-kinase/protein kinase B signaling pathway， activating the Nrf2 signaling pathway， improving insulin resistance， and reducing lipid deposition in the liver； exerts neuroprotective effects by activating the Nrf2/Keap1 signaling pathway， inhibiting the Toll-like receptor 4 and cyclic GMP-AMP synthase/stimulator of interferon genes signaling pathways to reduce neuroinflammatory damage； exerts bone protective effects by promoting tendon formation and inhibiting osteoclast differentiation； exerts antitumor effects by inducing tumor cell apoptosis and weakening tumor cell invasion and metastasis； and exerts antibacterial effects by downregulating α -toxin expression， interfering with β -lactamase/penicillin-binding protein 2a （PBP2a）， and inhibiting PBP2a oligomerization. Currently， research on the pharmacological effects of farrerol is still mainly focused on animal and cell experiments. Further mechanistic studies and clinical trials are needed to provide theoretical basis for its new drug development and clinical application. |
| 期刊： | 2026年第37卷第13期 |
| 作者： | 郤思远；马 寅；梁莹莹；连雯雯；马秉智；赫 军 |
| 英文作者： | XI Siyuan，MA Yin，LIANG Yingying，LIAN Wenwen，MA Bingzhi，HE Jun |
| 关键字： | 杜鹃素; 药理活性; 作用机制; 心脑血管; 抗肿瘤 |
| KEYWORDS： | farrerol; pharmacological activity; mechanism; cardiovascular and cerebrovascular; anti-tumor |
| 总下载数： | 81次 |
| 本日下载数： | 2次 |
| 本月下载数： | 81次 |
| 文件大小： | 619.60Kb |
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