炮制对巴戟天化学成分及药理作用影响的研究进展 点击下载
| 论文标题： | 炮制对巴戟天化学成分及药理作用影响的研究进展 |
| 英文标题： | |
| 中文摘要： | 巴戟天为“四大南药”之一，临床上常用于治疗肾阳不足所致阳痿遗精、宫冷不孕、月经不调、少腹冷痛、风湿痹痛、筋骨痿软等。基于“生熟异治”原则，本文梳理不同炮制方法对巴戟天中化学成分及药理作用的影响。研究发现，炮制会对巴戟天糖类、环烯醚萜类及蒽醌类成分的含量和结构产生影响，进而调控其抗骨质疏松、调节免疫、抗疲劳、抗抑郁等药理作用，其中盐巴戟天在抗骨质疏松、增强免疫等方面表现突出。尽管目前研究已初步明确了巴戟天的主要化学物质成分及其药理作用特征，但炮制过程中成分的动态转化路径仍需进一步阐明，尤其是建立与炮制工艺关联的质量标志物体系，以实现炮制工艺的精准化和智能化发展。 |
| 英文摘要： | Morinda officinalis is one of the “Four Great Southern Medicines” and is commonly used in clinical practice to treat erectile dysfunction and nocturnal emissions caused by kidney yang deficiency， uterine cold infertility， menstrual disorders， low abdominal pain， rheumatism， and muscle and bone weakness. Based on the principle of “treating raw and cooked differently”， this article summarizes the effects of different processing methods on the chemical constituents and pharmacological effects of M. officinalis . Research has found that processing can affect the content and structure of sugars， iridoids， and anthraquinones in M. officinalis ， thereby regulating its pharmacological effects such as anti-osteoporosis， immune regulation， anti-fatigue， and anti-depression. Among them， salt M. officinalis shows outstanding performance in anti-osteoporosis and enhancing immunity. Although previous studies have preliminarily elucidated the major chemical constituents of M. officinalis and their pharmacological characteristics， the dynamic transformation paths of constituents during the processing remain to be further clarified， especially the es tablishment of a quality marker system associated with the processing technology， to achieve the precision and intelligent development of the processing. |
| 期刊： | 2026年第37卷第13期 |
| 作者： | 白娜；付天義；马亚乐；王宸；李红伟；李凯；康乐；刘梦云 |
| 英文作者： | BAI Na，FU Tianyi，MA Yale，WANG Chen，LI Hongwei，LI Kai，KANG Le，LIU Mengyun |
| 关键字： | 巴戟天; 炮制; 化学成分; 药理作用; 生熟异治 |
| KEYWORDS： | Morinda officinalis; processing; chemical constituents; pharmacological effects; treating raw and cooked differently |
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