中药活性成分调控三羧酸循环抗动脉粥样硬化的研究进展 点击下载
论文标题： 中药活性成分调控三羧酸循环抗动脉粥样硬化的研究进展
英文标题：
中文摘要： 动脉粥样硬化（AS）的发生与内皮功能障碍及线粒体代谢异常等存在密切关联。这种异常本质上体现为细胞的代谢重编程，而三羧酸（TCA）循环作为介导该重编程的核心环节，其所引起的中间代谢物（如琥珀酸、α-酮戊二酸、衣康酸等）稳态失衡，可通过多种机制（如调控氧化应激、炎症及糖脂代谢网络）参与AS的发展进程。中药活性成分具有多靶点、多通路协同调控的特点，在改善代谢紊乱方面显示出独特优势。黄酮类、苷类等多种中药活性成分能够靶向调控TCA循环关键酶及其代谢物，通过纠正异常的代谢重编程网络，减轻氧化应激、炎症及糖脂代谢紊乱对血管内皮的损伤，进而改善代谢紊乱状态并抑制AS进展。
英文摘要： The development of atherosclerosis （AS） is closely associated with endothelial dysfunction and mitochondrial metabolic abnormalities. These alterations are fundamentally characterized by metabolic reprogramming， in which the tricarboxylic acid （TCA） cycle serves as a central regulatory hub. Disruption of the homeostasis of TCA cycle intermediates， including succinate， α -ketoglutarate， and itaconate， contributes to AS progression through multiple mechanisms， such as the modulation of oxidative stress， inflammation， and glucose and lipid metabolic networks. Owing to their multi-target and multi-pathway regulatory properties， bioactive compounds derived from traditional Chinese medicine （TCM） have demonstrated unique advantages in correcting metabolic dysregulation. Flavonoids， glycosides， and other bioactive constituents of TCM can target key enzymes and metabolites involved in the TCA cycle， thereby restoring aberrant metabolic reprogramming， alleviating endothelial injury induced by oxidative stress， inflammation， and glucose and lipid metabolic disorders， ultimately improving metabolic homeostasis and attenuating the progression of AS.
期刊： 2026年第37卷第13期
作者： 苏煜凯；张雅洁；张娜娜；刘畅；殷洪振；杨雨民
英文作者： SU Yukai，ZHANG Yajie，ZHANG Nana，LIU Chang，YIN Hongzhen，YANG Yumin
关键字： 中药活性成分; 动脉粥样硬化; 三羧酸循环; 炎症反应; 氧化应激; 糖脂代谢; 代谢重编程
KEYWORDS： bioactive constituents of traditional Chinese medicine; atherosclerosis; tricarboxylic acid cycle; inflammation; oxidative stress; glucolipid metabolism; metabolic reprogramming
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