丹参酮ⅡA改善脓毒症所致多器官功能障碍的作用机制研究进展 点击下载
| 论文标题： | 丹参酮ⅡA改善脓毒症所致多器官功能障碍的作用机制研究进展 |
| 英文标题： | |
| 中文摘要： | 脓毒症是一种因感染引发的全身炎症反应综合征，病情进展迅速，易发展为多器官功能障碍。丹参酮ⅡA是丹参的核心活性成分之一，对脓毒症所致多器官功能障碍具有显著的靶向保护效应。本文综述了丹参酮ⅡA改善脓毒症所致多器官功能障碍的作用机制，发现其可通过抑制Toll样受体4/髓样分化因子88/核因子κB、磷脂酰肌醇3-激酶/蛋白激酶B等信号通路活性，维持线粒体稳态等，改善脓毒症所致肺损伤；可通过抑制NOD样受体热蛋白结构域相关蛋白3/胱天蛋白酶1信号通路活性、下调炎症因子表达、调控自噬进程等，改善脓毒症所致心肌损伤；可通过调节氧化应激失衡、下调凋亡相关蛋白表达等，改善脓毒症所致肾损伤；可通过抑制炎症因子表达和肝细胞凋亡等，改善脓毒症所致肝损伤；可通过上调紧密连接蛋白表达、抑制炎症反应等，改善脓毒症所致肠屏障功能障碍；可通过激活过氧化物酶体增殖物激活受体γ共激活因子1α/核呼吸因子1/线粒体转录因子A信号通路等，改善脓毒症相关性脑病。丹参酮ⅡA有望成为脓毒症综合防治的重要候选药物，但需通过跨学科研究突破现有瓶颈，实现从基础实验向临床应用的转化。 |
| 英文摘要： | Sepsis is a systemic inflammatory response syndrome triggered by infection. It progresses rapidly and tends to develop into multiple organ dysfunction. Tanshinone ⅡA， one of the core active ingredients of Salvia miltiorrhiza， exerts remarkable targeted protective effects against sepsis-induced multiple organ dysfunction. This paper reviews the mechanisms by which tanshinone ⅡA alleviates sepsis-induced multiple organ dysfunction. Tanshinone ⅡA can relieve sepsis-induced lung injury by inhibiting the activity of Toll-like receptor 4/myeloid differentiation primary response protein 88/nuclear factor- κB， phosphatidylinositol 3-kinase/protein kinase B signaling pathways and maintaining mitochondrial homeostasis. It ameliorates sepsis- induced myocardial injury via suppressing the activation of NOD-like receptor family pyrin domain-containing 3/caspase-1 signaling pathway， downregulating the expression of inflammatory factors and regulating autophagy. It mitigates sepsis-induced renal injury by regulating oxidative stress imbalance and reducing the expression of apoptosis-related proteins. It alleviates sepsis-caused liver injury through inhibiting the release of inflammatory factors and hepatocyte apoptosis. It improves sepsis-induced intestinal barrier dysfunction by upregulating the expression of tight junction proteins and restraining inflammatory responses. Furthermore， it relieves sepsis-associated encephalopathy by activating peroxisome proliferator-activated receptor gamma coactivator-1α/nuclear respiratory factor 1/mitochondrial transcription factor A signaling pathway. Tanshinone ⅡA is expected to be a vital candidate drug for comprehensive prevention and treatment of sepsis. However， interdisciplinary research is required to break through current bottlenecks and realize the transformation from basic experiments to clinical application. |
| 期刊： | 2026年第37卷第15期 |
| 作者： | 杜婧雨；张瑞芬；李洋；苏和；贾婷婷；张海荣；黄新生 |
| 英文作者： | DU Jingyu，ZHANG Ruifen，LI Yang，SU He，JIA Tingting，ZHANG Hairong，HUANG Xinsheng |
| 关键字： | 丹参酮ⅡA；脓毒症；多器官功能障碍；作用机制；临床转化 |
| KEYWORDS： | tanshinone ⅡA； sepsis； multiple organ dysfunction； mechanism； clinical translation |
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| 文件大小： | 619.60Kb |
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