中药调控HIF-1α介导的糖酵解重编程重塑缺血性卒中免疫微环境的研究进展 点击下载
| 论文标题： | 中药调控HIF-1α介导的糖酵解重编程重塑缺血性卒中免疫微环境的研究进展 |
| 英文标题： | |
| 中文摘要： | 缺血性卒中（IS）是临床高发的严重脑血管疾病。脑组织缺血缺氧可诱导细胞糖酵解代谢重编程。缺氧诱导因子1α（HIF-1α）是缺氧应答的核心转录因子。本文系统综述了HIF-1α介导糖酵解重编程的分子机制，阐述该代谢改变对不同免疫细胞功能状态的影响，并总结了中药干预该病理过程的研究进展。HIF-1α可通过调控葡萄糖转运蛋白、糖酵解限速酶及线粒体氧化抑制因子等关键基因的转录，重塑葡萄糖代谢通量，推动细胞代谢向糖酵解模式偏移。该代谢紊乱能够调控小胶质细胞、星形胶质细胞及外周浸润免疫细胞的活化状态、表型分化与功能重塑，进而参与介导IS后神经炎症反应，且多条信号通路及糖酵解代谢产物乳酸可反向调控这一代谢-免疫进程。黄芪甲苷Ⅳ、丹酚酸C、银杏叶提取物、脉络舒通丸等多种中药活性成分及中药复方可通过调控AMP活化的蛋白质激酶/哺乳动物雷帕霉素靶蛋白/HIF-1α、HIF-1α/丙酮酸激酶M2型、HIF-1α/乳酸脱氢酶A等信号通路，抑制异常糖酵解、减少乳酸蓄积、恢复葡萄糖氧化代谢稳态，从而有效减轻神经免疫炎症反应，缓解缺血性脑损伤。 |
| 英文摘要： | Ischemic stroke （IS） is a serious cerebrovascular disease with high clinical incidence. Cerebral ischemia and hypoxia can induce metabolic reprogramming of cellular glycolysis. Hypoxia-inducible factor-1α （HIF-1α） serves as the core transcription factor in the hypoxic response. This article systematically reviews the molecular mechanisms of HIF-1α-mediated glycolytic reprogramming， elaborates on the effects of this metabolic alteration on the functional status of different immune cells， and summarizes the research progress of traditional Chinese medicine （TCM） interventions in this pathological process. HIF-1α reshapes glucose metabolic flux and shifts cellular metabolism toward glycolysis by regulating the transcription of key genes， including glucose transporters， glycolytic rate-limiting enzymes， and mitochondrial oxidative inhibitors. This metabolic disturbance can regulate the activation status， phenotypic differentiation， and functional remodeling of microglia， astrocytes， and peripherally infiltrated immune cells， thereby participating in the mediation of neuroinflammatory responses after IS. Moreover， multiple signaling pathways and the metabolite of glycolysis lactate can exert feedback regulation on this metabolic-immune process. Various active components of TCM and herbal formulas， such as astragaloside Ⅳ， salvianolic acid C， Ginkgo biloba extract， and Mailuo shutong pills， can inhibit abnormal glycolysis， reduce lactate accumulation， and restore the homeostasis of glucose oxidative metabolism by regulating signaling pathways including AMP-activated protein kinase/mammalian target of rapamycin/HIF-1α， HIF-1α/pyruvate kinase M2， and HIF-1α/lactate dehydrogenase A. Consequently， they effectively alleviate neuroimmune inflammation and attenuate ischemic brain injury. |
| 期刊： | 2026年第37卷第17期 |
| 作者： | 杜佳钰；王森雨；白琛；郝颖煦；刘向哲 |
| 英文作者： | DU Jiayu，WANG Senyu，BAI Chen，HAO Yingxu，LIU Xiangzhe |
| 关键字： | 缺氧诱导因子1α；糖酵解；乳酸化修饰；代谢重编程；免疫微环境；缺血性卒中；中药 |
| KEYWORDS： | glycolysis;lactylation modification;metabolic reprogramming;immune microenvironment;ischemic stroke;traditional Chinese medicine |
| 总下载数： | 81次 |
| 本日下载数： | 2次 |
| 本月下载数： | 81次 |
| 文件大小： | 619.60Kb |
* 注：未经本站明确许可，任何网站不得非法盗链资源下载连接及抄袭本站原创内容资源!在此感谢您的支持与合作！