环孢素A个体化用药临床预后的实验室检查指标研究进展 点击下载
论文标题: 环孢素A个体化用药临床预后的实验室检查指标研究进展
英文标题:
中文摘要: 环孢素A在器官移植以及自身免疫疾病治疗中应用广泛,由于该药存在明显的个体间代谢差异,临床使用时需要根据患者血药浓度调整给药剂量。但环孢素A的血药浓度并不能准确反映其临床预后。本文围绕外周血单个核细胞内环孢素A浓度、钙调磷酸酶活性和T细胞功能以及环孢素A代谢物浓度4个实验室检查指标,综述其与环孢素A药动学以及临床预后的相关性。结果发现以上指标对患者使用环孢素A的临床预后情况有一定的预示作用,可弥补血药浓度监测的不足,但其临床实用性还需进一步提高。
英文摘要: Cyclosporine A is widely used in organ transplantation and autoimmune diseases . Due to the obvious differences in metabolism between individuals ,the dosage should be adjusted according to the patient ’s blood concentration during clinical use . But the blood concentration does not reflect accurately its clinical prognosis . This article focuses on the four laboratory examination indexes following aspects :the cyclosporine A concentration of peripheral blood mononuclear cells ,calcineurin activity ,T cell function and metabolite concentration of cyclosporine A . The relationship between them and the pharmacokinetics of cyclosporine and clinical prognosis were reviewed . It’s found that the above indicators have a certain predictive effect on the clinical prognosis of patients receiving cyclosporine A ,which can make up for the insufficiency of blood drug concentration monitoring ,and the clinical practicability needs to be further improved .
期刊: 2022年第33卷第18期
作者: 胡锦炜,朱怀军,劳茜莹,李丹滢
英文作者: HU Jinwei ,ZHU Huaijun ,LAO Qianying ,LI Danying
关键字: 环孢素A;治疗药物监测;临床疗效;安全性;实验室检查指标
KEYWORDS: cyclosporine A ;therapeutic drug monitoring ;clinical effi cacy;safety;laboratory examination index
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