化疗患者5-羟色胺3受体拮抗剂路径化管理模式的建立与应用 点击下载
| 论文标题： | 化疗患者5-羟色胺3受体拮抗剂路径化管理模式的建立与应用 |
| 英文标题： | |
| 中文摘要： | 目的 建立化疗患者5-羟色胺3受体拮抗剂（5-HT3RA）路径化管理模式，提高化疗患者用药合理性。方法制定5-HT3RA规范化用药管控规则，并借助医疗智能及决策支持（MINDS）系统，以信息抓取结合医嘱前置审核的形式对使用5-HT3RA的化疗患者开展路径化管理，对用药指征、用法用量、疗程等实施全程化干预。通过比较实施路径化管理前后5-HT3RA无指征用药、用法用量不合理、重复用药、疗程不合理的变化情况以及5-HT3RA人均药费变化情况，对干预效果进行分析。结果共纳入9181例患者，实施路径化管理后，无指征用药率降低0.48%，单次剂量、给药频次、重复用药、疗程（化疗结束后3d仍使用5-HT3RA）的不合理率分别降低10.48%、0.65%、1.33%、0.34%，5-HT3RA人均药费降低13.72元，以上差异均有统计学意义（P＜0.05）。结论我院建立的化疗患者5-HT3RA路径化管理模式有效提高了用药合理性，为临床合理用药提供了新思路。 |
| 英文摘要： | OBJECTIVE To establish the path-based management mode of 5-hydroxytryptamine-3 receptor antagonist （5- HT3RA） in chemotherapy patients， and to improve the rationality of medication in chemotherapy patients. METHODS 5-HT3RA standardized drug use control rules were formulated， with the help of medical intelligence and decision support （MINDS） system， path-based management was carried out for chemotherapy patients using 5-HT3RA in the form of whole-process information capture and prescription pre-review， and whole-process intervention was implemented on medication indications， usage and dosage， course of treatment， etc. The intervention effect was analyzed by comparing the changes in the use of 5-HT3RA without indication， unreasonable usage and dosage， repeated medication， unreasonable course of treatment， and per capita drug cost before and after the implementation of path-based management. RESULTS A total of 9 181 patients were included. After the implementation of path- based management， the proportion of unindicated drugs decreased by 0.48%， and the rate of unreasonable single dosage， unreasonable frequency， repeated medication， unreasonable treatment course （5-HT3RA still used 3 days after chemotherapy） decreased by 10.48%， 0.65%， 1.33% and 0.34%； per capita cost of 5-HT3RA decreased by 13.72 yuan； there were statistical significance （P＜0.05）. CONCLUSIONS 5-HT3RA path-based management mode effectively improves the rationality of medication and provides a new idea for rational clinical drug use. |
| 期刊： | 2023年第34卷第04期 |
| 作者： | 高璐；李静；周晓；黄元；虞琳；宋慧珠；杨钰华 |
| 英文作者： | GAO Lu，LI Jing，ZHOU Xiao，HUANG Yuan，YU Lin，SONG Huizhu，YANG Yuhua |
| 关键字： | 5-羟色胺3受体拮抗剂；化疗患者；路径化管理；信息化 |
| KEYWORDS： | 5-hydroxytryptamine-3 receptor antagonist； chemotherapy patients； path-based management； informatization |
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