系统评价盐酸氨溴索注射液静脉滴注联合雾化吸入治疗新生儿 点击下载
论文标题: 系统评价盐酸氨溴索注射液静脉滴注联合雾化吸入治疗新生儿
英文标题:
中文摘要:

目的:系统评价盐酸氨溴索注射液静脉滴注联合雾化吸入治疗新生儿肺炎的疗效和安全性,以为临床提供循证参考。方

法:计算机检索PubMed、Medline、中国生物医学文献数据库、中国期刊全文数据库、中文科技期刊数据库和万方数据库,收集盐酸

氨溴索注射液静脉滴注联合雾化吸入(试验组)对比单用盐酸氨溴索注射液静脉滴注(对照组)治疗新生儿肺炎的随机对照试验

(RCT),对符合纳入标准的临床研究进行资料提取,并采用Cochrane 系统评价员手册5.1.0 进行质量评价,采用Rev Man 5.2 统计

软件进行Meta 分析。结果:共纳入14 项RCT,合计1 407 例患儿。Meta 分析结果显示,试验组患儿的临床总有效率[RR=1.19,

95%CI(1.13,1.24),P<0.001]显著高于对照组,咳嗽消失时间[MD=-1.75,95%CI(-1.91,-1.58),P<0.001]、气喘消失时间

[MD=-1.38,95%CI(-1.67,-1.08),P<0.001]、肺部啰音消失时间[MD=-1.44,95%CI(-1.77,-1.11),P<0.001]和住院天

数[MD=-2.04,95%CI(-2.25,-1.82),P<0.001]均显著短于对照组,差异均有统计学意义;两组患儿不良反应发生率比较差异

无统计学意义[RR=1.00,95%CI(0.49,2.05),P=1.00]。结论:盐酸氨溴索注射液静脉滴注联合雾化吸入治疗新生儿肺炎的疗效

和安全性均较好。

英文摘要:

OBJECTIVE:To systemically review the efficacy and safety of Ambroxol hydrochloride injection by intravenous

drip combined with aerosol inhalation in the treatment of neonatal pneumonia,and provide evidence-based reference for the clinical

treatment. METHODS:Retrieved from PubMed,Medline,CBM,CJFD,VIP and Wanfang Database,randomized controlled trials

(RCT)about Ambroxol hydrochloride injection by intravenous drip combined with aerosol inhalation(test group)versus Ambroxol

hydrochloride injection alone(control group)in the treatment of neonatal pneumonia. Meta-analysis was performed by using Rev

Man 5.2 software after data extracting and quality evaluating by Cochrane 5.1.0. RESULTS:Totally 14 RCTs were enrolled,involving

1 407 patients. Results of Meta-analysis showed the clinical efficacy[RR=1.19,95% CI(1.13,1.24),P<0.001] in test group

was significantly higher than control group,the time of cough disappearance[MD=-1.75,95%CI(-1.91,-1.58),P<0.001],

asthma disappearance[MD=-1.38,95%CI(-1.67,-1.08),P<0.001] and pulmonary rales disappearance [MD=-1.44,95%CI

(-1.77,-1.11),P<0.001] and hospitalization days[MD=-2.04,95%CI(-2.25,-1.82),P<0.001] were significantly shorter

than control group,the differences were statistically significant;and there was no significant difference in the incidence of adverse

reactions between 2 groups[RR=1.00,95%CI(0.49,2.05),P=1.00]. CONCLUSIONS:Both the efficacy and safety of Ambroxol

hydrochloride injection by intravenous drip combined with aerosol inhalation are good in the treatment of neonatal pneumonia.

期刊: 2016年第27卷第3期
作者: 池卫明,廖华
英文作者: CHI Weiming,LIAO Hua
关键字: 氨溴索;雾化吸入;新生儿;肺炎;Meta分析;疗效;安全性
KEYWORDS: Ambroxol;Aerosol inhalation;Newborn;Pneumonia;Meta-analysis;Efficacy;Safety
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