HPLC法测定复脉定颗粒中盐酸川芎嗪的含量 点击下载
论文标题: HPLC法测定复脉定颗粒中盐酸川芎嗪的含量
英文标题:
中文摘要: 目的:建立测定复脉定颗粒中盐酸川芎嗪含量的方法。方法:采用高效液相色谱法。色谱柱为Diamonsil C18,流动相为甲醇-1%醋酸水溶液(46 ∶ 54,V/V),流速为1.0 ml/min,检测波长为293 nm,柱温为30 ℃,进样量为10 μl。结果:盐酸川芎嗪检测进样量线性范围为0.021 0~0.126 2 μg(r=0.999 9);精密度、稳定性、重复性试验的RSD<1.1%;加样回收率为98.19%~99.88%,RSD=0.60%(n=9)。结论:该方法操作简便、结果准确,适用于复脉定颗粒中盐酸川芎嗪的含量测定。
英文摘要: OBJECTIVE:To establish a method for the content determination of ligustrazine hydrochloride in Fumaiding granule. METHODS: HPLC was performed on the column of Diamonsil C18 with mobile phase of methanol-1% Aqueous acetic acid (46 ∶ 54,V/V) at a flow rate of 1.0 ml/min, the detection wavelength was 293 nm, column temperature was 30 ℃, and the injection volume was 10 μl. RESULTS: The linear range of ligustrazine hydrochloride was 0.021 0-0.126 2 μg(r=0.999 9); RSDs of precision,stability and reproducibility tests were lower than 1.1%;recovery was 98.19%-99.88%(RSD=0.60%,n=9). CONCLUSIONS: The method is simple and accurate, and can be used for the content determination of ligustrazine hydrochloride in Fumaiding granule.
期刊: 2016年第27卷第9期
作者: 何效平,王贤英
英文作者: HE Xiaoping,WANG Xianying
关键字: 高效液相色谱法;复脉定颗粒;盐酸川芎嗪 ;含量测定
KEYWORDS: HPLC; Fumaiding granule; Ligustrazine hydrochloride; Content determination
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