某院氯吡格雷在脑梗死二级预防中的使用合理性分析 点击下载
论文标题: 某院氯吡格雷在脑梗死二级预防中的使用合理性分析
英文标题:
中文摘要: 目的:为提高氯吡格雷在脑梗死二级预防中的使用合理性提供参考。方法:对2013-2014年某院神经内科收治的471例急性脑梗死患者病历进行回顾性调查,统计氯吡格雷使用率及其与质子泵抑制剂(PPIs)、阿司匹林的联用情况,并分析其使用合理性。结果:氯吡格雷在脑梗死二级预防中的使用率为93.84%;与PPIs联用率为52.49%,其中51.72%无选药或联合用药依据;与阿司匹林联用率为40.72%,其中心源性脑梗死患者只占3.9%,非心源性脑梗死患者占96.1%,脑梗死复发高危患者占31.11%。结论:该院氯吡格雷在脑梗死二级预防中使用广泛,且与PPIs和阿司匹林联用率较高,指南遵从率低。氯吡格雷使用中应加强相关的药学服务工作,遵从循证医学证据,提高其使用合理性。
英文摘要: OBJECTIVE:To provide reference for improving the clopidogrel rational use in cerebral infarction secondary prevention. METHODS: Medical cases of 471 patients with acute cerebral infarction in neurology department in a hospital from 2013 to 2014 were retrospective surveyed to collect the utilization rate of clopidogrel and the combination of clopidogrel with proton pump inhibitors (PPIs) and aspirin, and the rationality was analyzed. RESULTS: The utilization rate of clopidogrel in cerebral infarction secondary prevention was 93.84%; the combination rate with PPIs was 52.49%, of which, 51.72% had no drug selection or combined treatment basis; the combination rate with aspirin was 40.72%, cardiogenic cerebral infarction accounted for only 3.9%, non-cardiogenic cerebral infarction accounted for 96.1%, and recurrence of cerebral infarction in high-risk patients accounted for 31.11%. CONCLUSIONS:Clopidogrel in patients with cerebral infarction secondary prevention is widely used in the hospital, has high combination rate with PPIs and aspirin and low guide compliance rate. Clopidogrel should be enhanced pharmacy services, comply with evidence based medicine and improve the rationality of medication.
期刊: 2016年第27卷第12期
作者: 孙银香,刘梓健,张建萍
英文作者: SUN Yinxiang,LIU Zijian,ZHANG Jianping
关键字: 氯吡格雷; 脑梗死; 二级预防; 合理使用
KEYWORDS: Clopidogrel; Cerebral infarction; Secondary prevention; Rational use
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