西地那非联合一氧化氮吸入治疗新生儿肺动脉高压的临床观察 点击下载
论文标题: 西地那非联合一氧化氮吸入治疗新生儿肺动脉高压的临床观察
英文标题:
中文摘要: 目的:观察西地那非联合一氧化氮(NO)吸入治疗新生儿肺动脉高压的临床疗效及安全性。方法:选取肺动脉高压患儿66例,按随机数字表法分为对照组与观察组,各33例。两组患儿均给予多巴胺注射液5 μg/(kg·min),ivgtt。对照组患儿吸入NO 5~20 ppm;观察组患儿在对照组基础上口服或鼻饲枸橼酸西地那非片0.5~1.0 mg/kg,6 h 1次。两组患儿均治疗3 d。观察两组患儿临床疗效及治疗前后动脉血氧分压(PaO2)、动脉血二氧化碳分压(PaCO2)、动脉血氧饱和度(SaO2)、肺动脉压(PAP)、NO、血清内皮素(ET-1)、缺氧诱导因子(HIF-1α)、促红细胞生成素(EPO)及Ca2+水平,并比较不良反应发生率。结果:观察组患儿临床总有效率为96.97%,明显高于对照组的75.76%,差异有统计学意义(P<0.05)。治疗前,两组患儿PaO2、SaO2、NO、PAP、PaCO2、ET-1、HIF-1α、EPO、Ca2+水平比较,差异无统计学意义(P>0.05);治疗后,两组患儿PaO2、SaO2、NO、Ca2+水平较治疗前明显升高,PaCO2、PAP、EPO、HIF-1、ET-1较治疗前明显降低,且观察组显著优于对照组,差异有统计学意义(P<0.05)。两组患儿均未见明显不良反应发生。结论:NO联合西地那非治疗新生儿肺动脉高压疗效显著,能有效改善患儿肺动脉高压体征及血气指标,且安全性较好。
英文摘要: OBJECTIVE: To observe clinical efficacy and safety of nitric oxide (NO) combined with sildenafil in the treatment of neonatal pulmonary hypertension. METHODS: 66 cases of neonatal pulmonary hypertension were selected and randomly divided into observation group and control group, with 33 cases in each group. 2 groups of patients were given Dopamine injection 5 μg/(kg·min), ivgtt. Control group was given NO 5-20 ppm;observation group received oral or nasal feeding of Citric acid sildenafil tablets, 0.5-1.0 mg/kg,96 h, on the basis of control group. Both group received 3 d of treatment. Clinical efficacy of 2 groups were observed as well as the level of PaO2, PaCO2, SaO2, PAP, NO, ET-1, HIF-1α, EPO and Ca2+ before and after treatment. The incidence of ADR was compared between 2 groups. RESULTS: Total effective rate of observation group was 96.97%, which was significantly higher than that of control group (75.76%), with statistical significance (P<0.05). There was no statistical significance in the levels of PaO2, PaCO2, SaO2, PAP, NO, ET-1, HIF-1α, EPO and Ca2+ between 2 groups before treatment (P>0.05); compared to before treatment, PaO2, SaO2, No and Ca2+ levels of 2 groups increased significantly after treatment, while PaCO2, PAP, EPO, HIF-1, ET-1 significantly lowered and the observation group was better than the control group, with statistical significance (P<0.05). No obvious ADR was found in 2 groups. CONCLUSIONS: Sildenafil combined with NO is effective in the treatment of neonatal pulmonary hypertension and can effectively improve pulmonary hypertension and blood gas indexes with good safety.
期刊: 2016年第27卷第20期
作者: 王乐男,张峥,买春芳
英文作者: WANG Lenan,ZHANG Zheng,MAI Chunfang
关键字: 一氧化氮;西地那非;新生儿肺动脉高压;疗效
KEYWORDS: Nitric oxide; Sildenafil; Neonatal pulmonary hypertension; Therapeutic efficacy
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