柏薏灌肠液的提取工艺研究 点击下载
论文标题: 柏薏灌肠液的提取工艺研究
英文标题:
中文摘要: 目的:优化柏薏灌肠液的提取工艺。方法:采用星点设计-响应面法。以盐酸小檗碱、阿魏酸和干膏率的总评归一值(OD)为评价指标,考察加水量和提取时间对提取工艺的影响;同时进行验证试验。结果:最优提取工艺为第1次加11倍水煎煮70 min,第2次加5倍水煎煮30 min。验证试验中第1次提取的OD值为0.940 0,与预测值偏差-2.07%;第2次提取的OD值为0.851 8,与预测值偏差-2.41%。结论:柏薏灌肠液的提取工艺合理可行,适用于工业化生产。
英文摘要: OBJECTIVE: To optimize the extraction technology of Baiyi rectal solution. METHODS: The effects of water amount and extraction time on extraction technology were investigated by central composite design-response surface method using OD value of berberine hydrochloride and ferulic acid and the extract yield as index. Validation test was also conducted. RESULTS: The optimal extraction technology was as 11-fold water, decocting 70 min for the first time; 5-fold water, decocting 30 min for the second time. In validation test, OD value of first extraction was 0.940 0, and the bias between observed and predicted values was -2.07%; that of second extraction was 0.851 8, and the bias was -2.41%. CONCLUSIONS: The extraction technology of Baiyi rectal solution is reasonable, feasible and suitable for industrial production.
期刊: 2016年第27卷第22期
作者: 李燕,赵利刚,王慧丽,郑丽娜,阚淑月
英文作者: LI Yan,ZHAO Ligang,WANG Huili,ZHENG Lina,KAN Shuyue
关键字: 柏薏灌肠液;星点设计-响应面法;盐酸小檗碱;阿魏酸;干膏率
KEYWORDS: Baiyi rectal solution; Central composite design-response surface methodology; Berberine hydrochloride; Ferulic acid; Extract yield
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