通脉颗粒水提及制粒工艺优化 点击下载
论文标题: 通脉颗粒水提及制粒工艺优化
英文标题:
中文摘要: 目的:优化通脉颗粒水提及制粒工艺。 方法:以浸膏得率和三七皂苷R1、人参皂苷Rg1、人参皂苷Re及人参皂苷Rb1的总皂苷量为评价指标,采用L9(34)正交试验法对通脉颗粒制备过程中的水提取工艺条件进行优化与验证;采用单因素分析对制粒工艺中的除杂、浓缩、干燥、制粒工艺进行优化与验证。结果:该颗粒剂水提取最佳工艺条件为8倍水,浸泡0.5 h,煎煮2次,每次煎煮1.0 h;验证试验中,浸膏得率为(28.38±0.461)%(RSD=1.63%,n=3),总皂苷含量为(5.029±0.060) mg/g(RSD=1.20%,n=3)。优化的制粒工艺为浸膏经翅片式过滤除杂,于真空度0.08 MPa、温度60 ℃下浓缩,按药粉-辅料(麦芽糊精)(3 ∶ 1,质量比)加入辅料,85~90 ℃干燥;采用干法制粒,稀释剂(麦芽糊精)的加入量为3%。在此条件下制备的样品的总皂苷含量为(5.211±0.207)mg/g(RSD=3.96%,n=3)。结论:该工艺合理可行、稳定可控,适用于通脉颗粒的制备。
英文摘要: OBJECTIVE: To optimize water extraction and granulating technology of Tongmai granule. METHODS: Using the contents of notoginsenoside R1, ginsenoside Rg1, ginsenoside Re and ginsenoside Rb1 and yield of extracts as the index, L9(34) orthogonal design was used to optimize and validate water extraction technology in preparation process of Tongmai granule. Decontamination, concentration and drying, diluent of granulating technology were investigated. RESULTS: The optimal water extraction technology was as follows as 8-fold water, soaking for 0.5 h, decocting 1.0 h each time, for 2 times. In validation test, the yield of extract was (28.38±0.461)% (RSD=1.63%,n=3), and the content of total saponins was (5.029±0.060) mg/g (RSD=1.20%,n=3). The optimized granulating technology was that extract was filtrated and decontaminated, and then concentrated under vacuum degree of 0.08 MPa and vacuum temperature of 60 ℃; the ratio of extraction powder-accessories (maltodextrin) was 3 ∶ 1, drying temperature was set at 85-90 ℃; the amount of diluent was 3%. Under this condition, the content of total saponins was (5.211±0.207) mg/g (RSD=3.96%,n=3) . CONCLUSIONS: This technology is stable and feasible, and it is suitable for the preparation of Tongmai granule.
期刊: 2016年第27卷第34期
作者: 尤文质,陈雪梅,苏娟娟,彭连共,管昌益
英文作者: YOU Wenzhi,CHEN Xuemei,SU Juanjuan,PENG Liangong,GUAN Changyi
关键字: 通脉颗粒;水提工艺;制粒工艺;正交试验;喷雾干燥
KEYWORDS: Tongmai granule; Water extraction technology; Granulating technology; Orthogonal test; Spray drying
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