黎药除湿祛风汤对鸡Ⅱ型胶原蛋白诱导关节炎模型大鼠的保护作用研究 点击下载
论文标题: 黎药除湿祛风汤对鸡Ⅱ型胶原蛋白诱导关节炎模型大鼠的保护作用研究
英文标题:
中文摘要: 目的:研究黎药除湿祛风汤对鸡Ⅱ型胶原蛋白诱导关节炎模型大鼠的保护作用。方法:将60只大鼠随机分为正常组、模型组、阳性组和除湿祛风汤高、中、低剂量组[45.9、22.95、11.48 g(生药)/kg],除正常组外,其余各组大鼠均以鸡Ⅱ型胶原蛋白诱导关节炎模型。建模后,除湿祛风汤各剂量组大鼠ig相应药物,正常组和模型组大鼠ig生理盐水,每天1次,连续给药12 d;阳性组大鼠实验1~3 d ig来氟米特4.5 mg/kg,4~12 d ig来氟米特1.8 mg/kg,每天1次。观察大鼠关节病变程度并进行评分,测定关节肿胀度和血清中肿瘤坏死因子α(TNF-α)、白细胞介素1β(IL-1β)和Ⅱ型胶原蛋白抗体水平。结果:与正常组比较,模型组大鼠关节炎指数评分、关节肿胀度及血清中TNF-α、IL-1β、Ⅱ型胶原蛋白抗体水平显著升高(P<0.01)。与模型组比较,阳性组和除湿祛风汤高剂量组大鼠病理评分显著降低,各给药组大鼠血清中TNF-α、IL-1β、Ⅱ型胶原蛋白抗体水平显著降低(P<0.05或P<0.01)。结论:黎药除湿祛风汤对鸡Ⅱ型胶原蛋白诱导模型大鼠具有一定的保护作用。
英文摘要: OBJECTIVE: To study the protective effects of Li medicine Chushi qufeng decoction on arthritis model rats. METHODS: 60 rats were randomly divided into normal group, model group, positive group and Chushi qufeng decoction high-dose, medium-dose and low-dose groups [45.9, 22.95, 11.48 g(crude drug)/kg]. Except for normal group, those groups were given chicken type Ⅱ collagen to induce arthritis model. After modeling, normal group and model group were given normal saline intragastrically, once a day, for consecutive 12 d; Chushi qufeng decoction groups were given relevant medicine intragastrically; positive group was given leflunomide 4.5 mg/kg on 1st-3rd day and 1.8 mg/kg on 4th-12th day. The degree of joint lesion in rats were scored. The degree of joint swelling was determined as well as the serum levels of TNF-α, IL-1β and type Ⅱ collagen antibody. RESULTS: Compared with normal group, arthritis index, degree of joint swelling, the serum levels of TNF-α, IL-1β and type Ⅱ collagen antibody increased significantly in model group (P<0.01). Compared with model group, pathological score of positive group and Chushi qufeng decoction high-dose group decreased significantly, and serum levels of TNF-α, IL-1β and type Ⅱ collagen antibody decreased significantly in treatment groups (P<0.05 or P<0.01). CONCLUSIONS: Li medicine Chushi qufeng decoction has certain protective effect on arthritis model rats induced by chicken type Ⅱ collagen.
期刊: 2016年第27卷第22期
作者: 张丽,张一云,符洪,王开裕,雷玲芳,王春桃
英文作者: ZHANG Li,ZHANG Yiyun,FU Hong,WANG Kaiyu,LEI Lingfang,WANG Chuntao
关键字: 黎药;除湿祛风汤;类风湿性关节炎;肿瘤坏死因子α;白细胞介素1β;大鼠
KEYWORDS: Li medicine; Chushi qufeng decoction; Rheumatoid arthritis; TNF-α; IL-1β; Rat
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