中药活性成分调控γδT细胞抗肿瘤免疫功能的研究进展 点击下载
| 论文标题： | 中药活性成分调控γδT细胞抗肿瘤免疫功能的研究进展 |
| 英文标题： | |
| 中文摘要： | γδT细胞兼具先天性与适应性免疫特征，其抗原识别不依赖经典的主要组织相容性复合体呈递，可直接识别肿瘤代谢异常，在免疫低浸润肿瘤中具有独特应用潜力。本文系统梳理γδT细胞的生物学特性及其抗肿瘤免疫功能特点，重点综述中药活性成分调控γδT细胞抗肿瘤免疫功能的相关机制，发现甘草多糖、黄芪多糖可通过促进多种细胞因子表达、调节肠道菌群、改善免疫抑制状态等，增强γδT细胞的抗肿瘤免疫功能；槲皮素和葛根素可通过调节γδT细胞的增殖、细胞毒效应分子表达及相关信号通路活性，增强γδT细胞介导的肿瘤细胞杀伤作用；川楝素可通过下调肿瘤细胞中抗凋亡蛋白表达，增强γδT细胞对肿瘤细胞的杀伤作用；青蒿琥酯可通过增强γδT细胞效应功能并减弱肿瘤细胞免疫逃逸能力，促进γδT细胞介导的抗肿瘤免疫效应。未来可重点探索中药活性成分与γδT细胞免疫治疗联合应用的协同效应及相关分子机制，明确γδT细胞发挥抗肿瘤免疫功能的关键靶点。 |
| 英文摘要： | γδ T cells possess both innate and adaptive immune characteristics. Their antigen recognition is independent of major histocompatibility complex presentation， and they can directly recognize abnormal tumor metabolism， showing unique application potential in tumors with low immune infiltration. This paper systematically sorts out the biological characteristics and antitumor immune functions of γδ T cells， and mainly reviews the relevant mechanisms by which active ingredients of traditional Chinese medicine regulate γδ T cells to exert antitumor immune functions. Glycyrrhiza polysaccharide and Astragalus polysaccharide can enhance the antitumor immune function of γδ T cells by promoting the expression of various cytokines， regulating intestinal flora and alleviating immunosuppressive state. Quercetin and puerarin can strengthen γδ T cell-mediated tumor cell killing by regulating the proliferation of γδ T cells， the expression of cytotoxic effector molecules and related signaling pathways. Toosendanin can potentiate γδ T cell-induced tumor cell killing by down-regulating the expression of anti-apoptotic protein in tumor cells. Artesunate can boost γδ T cell-mediated antitumor immune responses by enhancing the effector function of γδ T cells and weakening tumor immune escape. Future research shall focus on exploring the synergistic effects and molecular mechanisms of the combined application of active ingredients of traditional Chinese medicine and γδ T cell immunotherapy， and identifying the key targets for γδ T cells to exert antitumor immune functions. |
| 期刊： | 2026年第37卷第13期 |
| 作者： | 王彬睿；常峥；覃梅静；赵黎梅；莫娟梅；陆翔；卢春花 |
| 英文作者： | WANG Binrui，CHANG Zheng，QIN Meijing，ZHAO Limei，MO Juanmei，LU Xiang，LU Chunhua |
| 关键字： | γδ T细胞; 中药; 活性成分; 抗肿瘤; 免疫治疗; 免疫逃逸 |
| KEYWORDS： | γδ T cell; traditional Chinese medicine; active ingredient; antitumor; immunotherapy; immune escape |
| 总下载数： | 81次 |
| 本日下载数： | 2次 |
| 本月下载数： | 81次 |
| 文件大小： | 619.60Kb |
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