替奈普酶治疗急性缺血性脑卒中的快速卫生技术评估 点击下载
论文标题: 替奈普酶治疗急性缺血性脑卒中的快速卫生技术评估
英文标题:
中文摘要: 目的 评价替奈普酶治疗缺血性脑卒中的有效性、安全性和经济性,为临床合理用药和相关决策提供依据。方法系统检索PubMed、Cochrane图书馆、中国知网、万方数据以及卫生技术评估机构等官方网站,收集替奈普酶治疗急性缺血性脑卒中的系统评价/Meta分析、药物经济学研究和卫生技术评估报告,检索时限均为建库起至2024年6月30日。提取资料和评价质量后,对纳入研究的结果进行描述性分析。结果共纳入31篇文献,包括28篇系统评价/Meta分析和3篇药物经济学研究。有效性方面,与阿替普酶相比,替奈普酶(0.25mg/kg)可显著提高患者的早期神经功能改善率,且在90d优良神经功能预后率、90d良好神经功能预后率及血管再通率方面均不劣于阿替普酶。安全性方面,与阿替普酶相比,替奈普酶不会增加出血发生率、症状性颅内出血发生率、3个月全因死亡率及颅内出血发生率。经济性方面,国外研究结果显示,替奈普酶较阿替普酶具有经济学优势。结论与阿替普酶相比,替奈普酶治疗急性缺血性脑卒中的有效性和安全性均较好,且具有经济学优势。
英文摘要: OBJECTIVE To assess the efficacy, safety and cost-effectiveness of tenecteplase in the treatment of acute ischemic stroke, and to provide a basis for clinical rational drug use and related decision-making. METHODS The related literature in the PubMed, the Cochrane Library, CNKI, Wanfang data and health technology assessment (HTA) databases were searched from the establishment of the database to June 30th, 2024. Systematic reviews/meta-analyses, pharmacoeconomic studies and HTA reports on tenecteplase in the treatment of acute ischemic stroke were collected. After data extraction and quality assessment, descriptive analysis of the included studies was carried out. RESULTS A total of 31 articles were included, involving 28 systematic reviews/ meta-analysis and 3 pharmacoeconomic studies. In terms of effectiveness, compared with alteplase, tenecteplase (0.25 mg/kg) could significantly increase the early neurological improvement; the 90 d excellent neurological recovery rate, 90 d good neurological recovery rate, and recanalization were not inferior to alteplase. For safety, compared with alteplase, tenecteplase did not increase the incidence of hemorrhage, symptomatic intracranial hemorrhage, 3-month mortality, or intracranial hemorrhage. In terms of cost-effectiveness, foreign research results showed that tenecteplase had economic advantages over alteplase. CONCLUSIONS Compared with alteplase, tenecteplase is effective and safe in the treatment of acute ischemic stroke, and it is cost-effective.
期刊: 2024年第35卷第20期
作者: 邓晓媚;李会婷;门鹏;张哲弢;张瑾;史天陆
英文作者: DENG Xiaomei,LI Huiting,MEN Peng,ZHANG Zhetao,ZHANG Jin,SHI Tianlu
关键字: 替奈普酶;急性缺血性脑卒中;快速卫生技术评估;有效性;安全性;经济性
KEYWORDS: tenecteplase; acute ischemic stroke; rapid health technology assessment; effectiveness; safety; cost-effectiveness
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